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李任植

凝聚态

个人资料

  • 部门: 物理学院
  • 性别:
  • 出生年月: 1963-09-07
  • 专业技术职务: 教授
  • 研究标签:
  • 毕业院校:
  • 学位: PhD
  • 学历:
  • 联系电话: 15541943530
  • 电子邮箱: ilee@nankai.edu.cn
  • 办公地址: 5教-409
  • 通讯地址:
  • 邮编:
  • 传真:

教育经历

Ph.D in Bio(Polymer)-Physics H.H.Wills Physics Laboratory, University of Bristol, UK. Sept. 1989 – Jan. 1993 B.Sc. in Physics Pusan National University, Korea Mar. 1982 – Feb. 1986

工作经历

April. 2003 – Present Professor Institute of Physics, Nankai University, Tianjin, China Aug. 2002 – March 2003 Visiting Professor Tokyo Medical and Dental University, Japan July 1998 – July 2002 Sr. Researcher Department of Biomedical Engineering, Case Western Reserve University, USA July 1995– June 1998 Research Fellow - Department of Chemistry, University of Hong Kong, Hong Kong (June 1997-July 1998) - Institute of Chemistry, Chinese Academy of Sciences, Beijing, P.R.China (July 1995-June 1997) Dec. 1992 – June 1995 Assistant/Associate Professor Yanbain University of Science & Technology, Jilin, P.R.China Oct. 1991 – April 1992 Research assistant H.H. Wills Physics Laboratory, University of Bristol, UK

个人简介

1962年9月出生于韩国。1986年毕业于韩国釜山大学物理学系,获学士学位。1993年于英国Bristol大学物理学系获博士学位。后工作于英国、中国、美国和日本,历任英国Bristol大学(H.H.Wills物理学实验室)研究员,中国延边科学技术大学副教授,中国科学院化学研究所客座教授,香港大学客座教授,美国Case Western Reserve大学责任研究员,日本东京医科齿科大学客座教授等。现任中国南开大学物理学院生物物理系特聘教授。 主要从事生物界面方面的研究工作。在单分子和单分子界面相互作用,单分子和医用材料界面相互作用,单分子和单细胞界面相互作用方面取得了多方进展,先后在 Journal Applied Physics Letter, Surface Science, Biomaterials, PLoS ONE等杂志上发表;发表国际学术会议论文~100多篇。由于pN尺度上对单分子进行的一些研究,曾多次应邀参加学术会议阐述相关科研内容。2000年5月15日在国际生物材料学会第四次会议上获得优秀青年科学工作者奖。另外,还参与了 Surface Science, Ultramicroscopy, PLoS ONE, Biomaterials等十几种国际性刊物的某些评审工作。

研究领域

Questioning how the physical signals convert into the physiological signals, I have beeninterested in three main fields, bio-interfaces,physio-(eg. Mechanical / electromagnetic)interfaces, and chemo-interfaces;

1.Bio-interfaces:Nanotechniques make a possible to study singlemolecular kinetics at thenanobiointerface including ligand-receptor interactions. Applying dynamicmeasurement of the interaction, energy landscape could be understood at theligand-receptor binding. (Example: Single molecular GPIIb3a-RGD ligandinteraction,Surf. Sci 2001, 491: 433-443)

2.Chemo-interfaces: Biomimetic and bio-pattern studies: designing Biomimetic molecules and characterizing theirinterfacial properties at the single molecular level. The cellularnano-interfaces were also applied in controlling cell growth patterns.(Example:Biomimetic nanohydrogel, Biomaterials, 2004, 25,1911-1918). This work included the computer modeling and molecular designs.

3.Physio-interfaces:The conventional stimuli were considered only in biochemical stimulus. Myresearch investigates the physical stimuli such as mechanical, optical(electromagnetic) and thermal stimuli at the cells. How the cells respondingagainst physical stimuli is studying with combination of optical andbiophysical techniques. Another crucial question is how the physical stimuliwere converted into the physiological signals. From conventional staticphysical stimuli to dynamic stimuli is on characterizing. Those results willbuild a new paradigm in controlling biological functions with physicalstimulus. My current research topics were;

-Mechanotransduction; Mechanical stimuli interact directly with cytoskeleton dynamicsand submembrane molecules, which are correlated with the physiologicalfunctions. Due to the dynamic responses of a living cell, dynamic stimuli interms of frequency, resting intervals, and amplitude are applied andcharacterized. Micro-fluid multishear channel was applied on this approach.(Example: Fig Microfluid mulitshearstress channels, BBRC 2011, 408, 350–355)

-(Ir)radiation transduction; Optical sources were very good tools to monitor thebiological activities. However, it has not been considered, as an opticalsource itself is a stimulus in triggering the biological function. (Example:Fig. Frequency and intensity dependent signal, a) Empirical devices, BBRC 2010, 396, 662-666and b) Ca2+ signal of our theoretical model, Chin Phys Lett, 2009.26,1 017102).

-Bio-signal pattern analysis: Bio-signals exposing the specified biological functionswere interested to de-cord. Biological and biochemical functions werecorrelated with the physical biosignals. The biosignals were attempted todetect by applying nano-senses, and obtained the signals were decording tocharacterize the corresponding biological functions.










教学工作

Molecular Biophysics (Undergraduate)

                        Nanobiophysics(Graduate)

Theoretical Biophysics (Graduate)

Biophysics (Undergraduate)


科研项目

NSFC(National Science Foundation ofChina,2012-15)

NSFC(2011-13) PI

TJBSF(Tianjin Basic ScienceFoundation, 2007-10) PI

NSFC( 2006-7) PI

Ministry of Education, China (PhD Supervisor Fund, 2005-7) PI

Fund for the outstanding Prof.,Nankai Univ. ( 2003.4-2005.3); PI

Japanese Ministry of Sport,Culture and Education 2002.7-2003.9); PI

NationalInstitute Health Fund (1998-2002)  4rdparticipant



论文著作


70. P Jiang; F Xing; B Guo; J Yang; ZLi; F Hu; I Lee; X Zhang; L pan; J Xu(2017) Nucleotide transmitters ATP andADP mediate intercellular calcium wave communication via P2Y12/13 receptorsamong BV-2 microglia. PLoS One 2017 11;12(8):e0183114. Epub

69. Y Cao, X Wu, R Yang, X Wang, H Sun, I Lee (2017)Self-assembling Study of Sarcolipin and Its Mutants in Multiple MolecularDynamic Simulations. Proteins, doi:10.1002/prot.25273

68.Y Cao, XWu, X Wang, H Sun, I Lee (2016) Transmembrane dynamics of the Thr-5 phosphorylatedsarcolipin pentameric channel. Archives ofBiochemistry and Biophysics. 604:143–151.

67. G Nan, Y Zhang, S Li, I.Lee, T takano, S Liu.(2016) NaCl stress-induced transcriptomicsanalysis of Salix linearistipularis (syn. Salix mongolica). Biol Res Thesal. DOI10.1186/s40709-016-0038-7

66. Y Cao, X Wu, I Lee*, X Wang (2015) Molecular dynamics of water and monovalent-ions transportation mechanismsof pentameric sarcolipin.Proteins. 2015 Nov 2. doi:10.1002/prot.24956.

65.Fen Hu· Fulin Xing· Ge Zhu· Guangxue Xu· Cunbo Li· Junle Qu· Imshik Lee · Leiting Pan (2015) Rhein antagonizes P2X7 receptor in rat peritoneal macrophages. Scientific Reports09/2015;5:14012. DOI:10.1038/srep14012

64. C Yang, S Ma, I Lee, J Kim, S Liu (2015)Saline-induced Changes of Epicuticular Waxy Layer on the Puccinelliatenuiflora and Oryza sativa Leave Surfaces, Biological Research,48:33 (doi:10.1186/s40659-015-0023-x)

63. D Lee, J Lee, I.Lee, (2015) Cell Phone Generated RadioFrequency Electromagnetic Field Effects on the Locomotor Behaviors of theFishes Poecilia reticulata and Danio rerio, Int. J. Radiation Biology,91(10): 843-850.( DOI:10.3109/09553002.2015.1062575)

62. M Choe, W. Choe, I.Lee*, M Wu, S Liu(2015) ComputationalAnalysis of Mutated AHAS Appeared by Sulfonylurea (SU) Herbicides, WeedResearch, 55: 359-369.

61. Fen Hu, Leiting Pan, Kai Zhang, Fulin Xing, XinyuWang, Imshik Lee, Xinzheng Zhang, Jingjun Xu (2014) Elevation of ExtracellularCa2+Induces Store-Operated Calcium Entry via Calcium-Sensing Receptors: APathway Contributes to the Proliferation of Osteoblasts. PLoS ONE, 9: e107217

60. YuanyuanBu, Bo Sun, Aimin Zhou, Xinxin Zhang, Imshik Lee andShenkui Liu (2013) Identification and characterization of a PutAMT1;1gene from Puccinellia tenuiflora(2013) PLoS ONE8(12): e83111

59. GuixianMeng; Leiting Pan, Cunbo Li; Fen Hu; Xuechen Shi; Imshik Lee; Irena Drevensek-Olenik;Xinzheng Zhang; Jingjun Xu, (2014) Temperature-induced Labelling of Fluo-3 AMSelectively Yields Brighter Nucleus in Adherent Cells, BBRC, 443;888-893

58.L Pan, K Song, W Sun, F Hu,I Lee*(2013) Nitric oxideinduces Ca2+ entry by activating TRPV1-like channel viaS-nitrosylation in osteoblasts: an implication of the pathogenesis ofinflammation-mediated osteoporosis.Eu.J Pharm, 715; 280-285

57. X Wu, L Pan, Y Liu, P Jiang,I Lee, I Drevensek-Olenik, X Zhang, J Xu(2013) Cell-cell communication induces random spikes of spontaneous calciumoscillation in multi-BV-2 microglial cells. BBRC, 431;664-669.

56. X Kong, J Zhang, X Han, P Zhang, X Dai,J Liu, X Zhang, I Lee, S Liu,(2013) High-Yield production in E. coli of fungal_immunomodulatory protein isolated from Flammulina velutipes and its bioactivity assay in vivo, Int. J. Mol. Sci., 14; 2230-41.

55. Gao C-Y, Meng GX, Li X, Wu M, Liu Y, Li XY, Zhao X, Lee I, Feng X (2013)Wettability of dragonfly wings: the structure detection and theoreticalmodeling, Surf. InterfaceAnal.,45; 650–655,

54. Pan.L, Wang X, Yang S, Wu X, Lee I, Zhang X, RuppRA, Xu J (2012) Ultraviolet Irradiation-Dependent Fluorescence Enhancement ofHemoglobin Catalyzedby ROS, PLoS ONE 7(8) e44142.

53. Pan L, Wu X, Zhao D, Hessari NM, Lee I, et al. (2011) SulfhydrylModification Induces Calcium Entry through IP3-Sensitive Store-Operated Pathwayin Activation-Dependent Human Neutrophils. PLoS ONE 6(10): e25262.

52. Y.Cui,Y.J. Oh,J.Lim, M.Youn,I..Lee,H.K.Pak,W.Park,W.Jo,S.Park, (2012) AFM studyof the differential inhibitory effects of the green teapolyphenol () epigallocatechin3gallate (EGCG) against Gram-positive and Gram-negative bacteria, FoodMicrobiology, 29, 80-87

51. S Kou, L Pan,D van Noort, G Meng, X Wu, H Sun, J Xu,I Lee*, (2011) A microfluidicmultishear device for quantitative analysis of Calcium in osteoblasts,BBRC, 408 (2011) 350–355

50. S Kou, G Meng,L Pan, X Wang, Z Ju,I Lee* (2012)Computation Simulation and Application for Novel Microfluidic MultishearDevice, Acta ScientiarumNaturalium Universitatis Nankaiensis,2012,45(2): 31~36

49Ge Q, LeeI* (2011) Kinetics of Swelling/ShrinkingRearrangement of a Self-aggregated Nanohydrogel at Solid/Liquid , J Exp. Nanosci., 6(5),509-520

48. X Zhang,X Liu, L Pan, I Lee*,2010Magnetic Fields at ExtremelyLow-Frequency (50 Hz, 0.8 mT) Can Induce the Uptake of Intracellular CalciumLevels in Osteoblasts, Biochem. Biophys. Res. Com. (BBRC),396, 662-666

47. LuoM, Song K, Zhang X, Lee I,(2010) Replyto Comment on Mechanism for Alternating Electric Fields Induced-Effects onCytosolic Calcium, Chinese Physics Letters, 27,049902.

46. X Liu, XZhang, and I Lee* (2010) A quantitative study onmorphological responses of osteoblastic cells to fluid shear stress. ActaBiochimica et Biophysica Sinica 42(3):195-201;

45. Lou M, Song k, Zhang X, Lee I* (2009)Mechanism for Alternating Electric FieldsInduced-Effects on Cytosolic Calcium, ChinPhys Lett, 26(1) 017102.

44. 罗明艳,陈梅宗,李任植*2008αllbβ3同源模拟和环形RGD药物小分子设计. ChinJ Biotech, 24(2): 297-301

43.罗明艳,张旭,宋昆,李任植*(2009) 交变电场诱导胞浆内钙离子变化的机制。中国科技论文01-243

42. 罗明艳,宋昆,陈梅宗,李任植*(2009) 整合蛋白αIIbβ3的结构的同源模拟。中国科技论文,01-750

41.罗明艳,孙海英,宋昆,陈梅宗,李任植*(2009)环形x-RGD-y药物小分子设计、对接筛选。中国科技论文,01-982

40. XZhang, X Lu, J Sun, S He, I Lee*, H Pak, (2008) Real-time Observations of Nanopoint StimulusInduced Enhancements of Mechanical Properties in Osteoblast Cells, Ultramicroscopy 2008;108(10):1338-41.

39. M Luo, M Chen,I Lee*  (2008) αIIbβ3 modelingsimulation and design of the cyclic RGD, Chin.J of Biotechnology. 24(2), 297-301

38. SuJ, Liu Y, SongK, He S, Lee I, (2007)The study of the surface-enhanced Raman spectroscopy of osteoblast after thestimulation of electric currentCRTER,11(44), 8839

37 I Lee, H Sun, J Song, Y Zhang, (2008) Kinetics ofthe Self-assembled Nanohydrogels at a Hydrophobic Interface,JNN(Journal of Nanoscience and Nanotechnology), 83386-3391

36. K. Song, JY Su, SJ He,I.Lee*, (2007)Real-time Raman spectra of osteoblasts in pulsed electromagnetic field with lowfrequency and amplitude. CRTER (Clinical Rehabilitative TissueEngineering Research), 11(40), 8090-94

35Zou ZQ, Liu YN, Wu Y, Li QN,Chen MZ, Sun HY,Lee I*.(2007) Surface-enhancedRaman spectra of oxidation damnification of fetal bovine serum by ozone, Spectroscopy and Spectral Analysis, 27(6) 1140-2 (in Chinese)

34. I.Lee*, K Kobayashi, HY Sun, S Takatani, LG Zhong, (2007) Biomembrane mimetic polymer Poly(2-methacryloyloxyethylphosphorylchroline -co-n-butyl methacrylate) at the Interface of Polyurethane Surfaces , JBiomat. Res.A 82, 316-22

33. I.Lee*, K-Y.Chan, and D.I.Phillips (2004) “2D Dendrites and 3D Growth ofElectrodeposited Platinum Nanocrystals” Japanese Journal of Applied Physics,43,767-770

32. I.Lee* and K. Akiyoshi (2004) “Single Molecular Mechanics of aCholesterol-Bearing Pullulan Nanogel at the Hydrophobic Interfaces”Biomaterials, 25, 1911-1918

31. I.Lee and R.E. Marchant, (2003) “Molecular interaction studies ofhemostasis: fibrinogen ligand-human platelet receptor interactions" Ultramicroscopy97, 341-352

30.R.E.Marchant, I.Kang, P.S.Sit, B.Tadd, S.J.Eppell and I.Lee(2002)   “Molecular views and measurements ofhemostatic processes using atomic force microscope (Review article)” CurrentPeptide & Protein Science, 3(3), 249-274.

29. I.Leeand R.E.Marchant (2001)“Forcemeasurements on the molecular interactions between ligand (RGD) and humanplatelet αIIbβ3 receptorsystem” Surface Science. 491: 433-443

28. I.Lee and R.E.Marchant (2000)“DynamicDebonding Force Measurements of Ligand (RGD) and Platelet Receptor (GPllb/llla) System under Physiological Conditions.” Microscopy and Microanalysis,6, 974-975.

27.I.Lee, and R.E.Marchant (2000)"ForceMeasurements of Platelet Surface with High Spatial Resolution underPhysiological Conditions"Colloid & Interface B, 19, 357-365.

26. Zhu CF, Lee I, Li JW, Wang C, Cao XY, Xu H, Zhang RB (1999) "Atomic Force Microscopy Study ofSmall-size Nanotubular Polymer Thin Films"J. Mat. Res. 14: (3)1084-1090.

25. L.Yang,C.Bai, C.Liu, X.Shi, and I.Lee(1999)"TheoreticalStudies on Conformation Comparison of Braid-like and Triplex DNA"J. Mol. Str., 477, 7-13.

24. 李清,白春礼,Imshik Lee,杨林静,邓文礼,王琛,王乃新,刘次全(1999),溴代胞嘧啶对三螺旋 DNA 稳定性的影响; 计算机与应用化学,16(1), P9-13(In Chinese)

23杨林静, 白春礼,李任植,汪新文, 王琛(1998), Loop 环对分子内三螺旋DNA稳定性的影响; 中国科学B,28(1), P65-70 (InChinese)

22. 杨林静, 李任植, 王琛, 刘峁子, 苏明, 白春礼(1998),Loop 序列对双分子三螺旋DNA稳定性的影响, 中国科学C, 28(6), P496-500(In Chinese)

21.I.Lee, K-Y.Chan, and D.I.Phillips (1998) "Growthof Electrodeposited Pt Nanocrystals Studied by AFM" Appl. Surf.Sci.,136, 321-330 .

20. I.Lee, K-Y.Chan, and D.I.Phillips (1998) "AFM ofPlatinum Nanoparticles Prepared on HOPG".Ultramicroscopy, 75,69-76.

19. L.Yang, I.Lee, C.Wang, M.Z.Liu, M.Su, and C.Bai (1998) "Influence of Loop Sequenceon Relative Stability of Biomolecular Triplex DNA"Sciencein China C, 41, 381-386.

18. I.Lee, X.Wang, C.Zhu, C.Wang and C.Bai (1998)"AFMImage Analysis of Polystyrene Nanoparticle and DNA-protein Complex with ImageReconstruction"Appl. Surf. Sci., 126, 281-286.

17. L.Yang,X.Fung, I.Lee, C.Bai (1998) "Structure Studies on Host +Guest Recognition Sensory Systems"J Inclus.Phenom. Mol 31, 197-204.

16. L.Yang, I.Lee, C.Wang, Q.Li, C.Bai (1998) "Loop and Water Effect onStability of Intratriplex DNA" J.Mol.Str. 442, 275-280 .

15. L.Yang,X.Fung, I.Lee, C.Bai (1998) "MolecularStructure of Recognition System Host+Guest and DNA Complex" J.Mol.Str.444, 13-20

14. L.Yang,X.Fung, I.Lee, and C.Bai (1997) "StructuralStudies on Host-Guest Recognition Sensory System" Chinese Chem. Lett., 8,707-710.

13. L.Yang,C.Bai,I.Lee, X.Wang, C.Wang(1997) "Effectof Loop on Stability of Intramolecular Triplex DNA" Science in China B. 40,650-656.

12. C.Liu,Z.Zhang, L.Lai, C.Bai, W.Li, R.Wang, I.Lee and Y.Tang (1997)"mRNAProbably Carries The Three-dimensional Genetic Information"ZoologicalResearch (China). 18, 138.

11. I.Lee, W.Deng, C.Wang and C.Bai (1997) "BiphasicTransition of a Hairpin Hexanucleotide Triplex DNA" Biophys.Chem., 67,159-165 .

10. I.Lee, Q.Li, L.Yang, X.Wang, W.Deng, C.Wangand C.Bai (1997) "Polarity Modified Triplex DNA byBromide" Chinese Sci. Bull, 42, 1581-1584.

9. I.Lee, C.Bai and C.Wang (1997) "Scanning TunnellingMicroscopy Studies of Algal Polysaccharide: Gelation of Carrageenan"J.Chin.Electr.Microscopy Soc., 16, 710-713.

8. I.Lee(1997) "X-ray Diffraction Patterns fromOriented Samples of iota- and kappa-carrageenan and Implications forConformational Transition"Polymer (Korea) 21,539-548.

7. I.Lee, C.Bai, C.Wang and X.Wang (1997)  "Computational Analysis of TriplexFormation of Oligonucleotides: Protonated and 5'-methylated Py-Pu-PyMotif" Science in China B, 40(1) 113-121.

6. I.Lee, C.Bai, X.Wang and N.Wang (1997) "Chemical Cross-linkedGelation of HPG under Shear Flow" Polymer J., 29, 17-20.

5. I.Lee, C.Bai and C.Wang (1996) "Conformational Studies ofArabinoglucuronomannoglycan (AGM)" Acta Biophysica Sinica, 12,547-553.

4. C.Wang,C.Bai, X.Li, G.Shang, I.Lee, X.Wang,X.Qiu and F.Tian (1996)"Evidence of DiffusionCharacteristics of Field Emission Electron in Nanostructural Process onGraphite Surface" Appl.Phys.Lett., 69, 348-350.

3. I.Lee (1992) "The Conformational andNano-structural Studies of Macromolecules" PhD Thesis, University ofBristol, UK.

2. I.Lee, E.D.T.Atkins, and M.J.Miles (1992)"Visualisation ofthe Algal Polysaccharide Carrageenan by Scanning Tunnelling Microscopy"Ultramicroscopy, 42/44,1107-1112.

1.M.J.Miles, I.Lee and E.D.T.Atkins (1991) "MolecularResolution of Polysaccharides by Scanning Tunnelling Microscopy"J.Vac.Technol.,B9(2),1206-1209.



学术交流

1x4.Effectsof Extremely Low Frequency Electromagnetic Fields on Cation Transport in AtCAX5 Expressing Yeast (2013) , Northeast ForestryUniversity, China

1x3. Structuraland Computational Analysis of Mutated ALS Appeared by SU(Sulfonylurea)Herbicides (2013), 11th annual meeting for Chinese Weedy Society, Changsha,China.

1x2.(Invited lecture)Computer-aided molecular modelingand design (2013) China-Korea-DPRK Joint Seminar, Yanbian Univ. China

1x1. Real-time Study of SinusoidalElectromagnetic Fields Induced Intracellular [Ca2+]i Responses in theOsteoblast Cells (2013) Progress InElectromagnetics Research Symposium, Taiwan

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                         .

                         .

28. (Invited lecture) Physical Induced stimuli on theliving cells (2010), Incheon Univ., Korea

27  Real-timeObservations of Magnetic Field Induced Changes in Osteoblast Cells (2009) 5th EMF, Hangzhou, China

26 Physical Stimuli induced effects on Osteoblasts.The 14th Workshop of Statistical Physics, Aug. 2007, Nami Island,Korea

25  Real-timeObservation of Nanopoint Stimulus Induced Enhancements of Mechanical Propertiesof Osteoblast Cells, 2007 ISPM,  June2007, Jeju, Korea

25,  Swellingand flattening manipulation of a self-assembled nanohydrogels,  2007 China Nano, June 2007, Beijing China

24. Biomechanics and Nanobiointerfaces, The 2ndSummer Workshop-Applications of Nao-intelligent Materials for Biosensing, Aug2006, Seoul Korea.

23.(Invited Lecture) Single Molecular Mechanics at the Biointerfaces, Ewha NanoBioInternational Symposium (2004) Seoul, Korea

22The hemocompatibility characterization of MPC polymer in vivo using AFM andSEM, SPM, sensor and Nanostructures(2004) Beijing-TEDA, China

21. (Japanese)Stability studies of methacryloyloxyethyl phosphorylcholine (MPC) modifiedArtificial pulsed heart surfaces, Japanese Society for Biomaterials (2003 Dec)

20 (InvitedLecture) Nanointerfaces to Biomaterials, 2003, Tokyo Institute of Technology,Japan,  

19. (InvitedSpeaker) Nanoscale Biointerfaces (2003) International Symposium-Application ofNanobiotechnology for Biomaterials and Artificial Organs, Tokyo, Japan.

18.Biointerfacial Characteristics in the Regulation of Thrombosis and ItsMimetics, International Association for Dental Research-Dental Materials GroupChapter-Japan(IADR-DMGC-J), 2002, Tokyo, Japan.

17. MolecularInteraction Studies of Hemostasis:Fibrinogen Ligand-Human Platelet ReceptorInteractions, Las Vegas 2002 Scanning Probe Microscopy, Sensors andNanostructures

16. ForceMeasurements of the molecular interaction between ligand (RGD) and humanplatelet GP llb/llla receptor. International Society of Thrombosis andHemostasis,  2001, Paris, France

15.Dissociation Energies for Single Molecular Ligand (RGD)-Platelet Receptor (GPIIb/IIIa) Interactions Determined by AFM under Physiological Conditions. The2001 Annual Meeting of  Society forBiomaterials. April 24-29,2001,  SaintPaul, USA.

14.Measurement of single molecular interaction force between fibrinogen andplatelet membrane receptor glycoprotein IIb/IIIa in vitro (2000) 9thMidwest Platelet Conference, Cleveland, USA.

13. (InvitedSpeaker) Nanoscopic studies of Ligand-receptor interaction (2000), Microscope& Microanalysis 2000 (M&M 2000), Philadelphia, USA.  

12. (InvitedLecture) Single molecular  dynamics atthe interfaces (2000) University of Waterloo, ON Canada

11. Timedependent changes in human neutrophils observed by AFM (2000), World Congresson Medical Physics and Biomedical Engineering, Chicago. USA

10. Directforce measurement of RGD ligand and platelet receptor GPllb/lla underphysiological conditions (2000), World Congress of Biomaterials, Hawaii,USA.

9.  (Invited Lecture) Electromagnetic fieldeffects at bio-molecular via cellular level (1999), Korea Electric ResearchInstitute, Korea

8. AFM imagesand direct force measurements of platelet surface under physiologicalconditions (1999) Seattle’99: AFM, Seattle, USA

7.Investigations of DNA Structure Using SPM and Related Techniques (1996) AnnualMeeting of Int'l Society of Electrochemistry -47th Meeting, Veszprem,Hungary.

6. Effects ofField Emission Electrons in Nanostructural Processes (1996) NANO IV, Beijing,China.

5 AFM Studiesof SCPS Molecule (1996) NANO IV, Beijing, China

4. ScreeningEffects on triplex DNA by Hydration (1996) Structural Biology Conference(Chinese), Chingdao, China.

3. X-raydiffraction Studies of Carrageenan and Implication into Gelation (1992)Macromolecules '92 : Functional Polymers and Biopolymers, Univ. of Kent,Canterbury, UK.

2. New FoldingMechanism for Nylon 46 (1991) Binal UK Polymer Conference, Univ. of Leed,UK.

1.STM Studies ofPolysaccharides (1991) '91 STM Conference, Interlaken, Switzerland.


荣誉奖励

Travel Awards for an outstanding young scientists (2001, Congress ofBiomaterials)

Outstanding Paper at 11th annual assembly of Chinese Weed Society,Changsha, China(2013)


学术成果

学位: PhD

毕业院校:

邮件: ilee@nankai.edu.cn

办公地点: 5教-409

电话: 15541943530

出生年月: 1963-09-07

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